Snake trippetide

Snake trippetide - Names and Identifiers

Name	(2S)-beta-Alanyl-L-prolyl-2,4-diamino-N-(phenylmethyl)butanamide acetate
Synonyms	SYN-AKE snake-tripeptide Snake trippetide Syn-Ake, Snake trippetide H-β-Ala-Pro-Dab-NHBzl.2AcOH Dipeptide Diaminobutyroyl Benzylamide Diacetate (2S)-beta-Alanyl-L-prolyl-2,4-diamino-N-(phenylmethyl)butanamide acetate
CAS	823202-99-9

Snake trippetide - Physico-chemical Properties

Molecular Formula	C19H29N5O3.2(C2H4O2)
Molar Mass	495.58
Appearance	White powder
Storage Condition	-20℃
Use	Snake-like peptide is a small peptide that mimics the activity of snake venom toxin, not snake venom. It is an active peptide similar to the structure of snake venom toxin. Snake-like peptides are 5 times more effective in reducing dynamic lines than botulinum. Human tests have found that they can effectively reduce 52% wrinkles after 28 days of use.

Snake trippetide - Introduction

Sequence: H-β-Ala-Pro-Dab-NH-Bzl

Last Update：2022-10-16 17:30:59

Snake trippetide - Introduction

background snake venom peptide is a substance secreted by venomous snake glands, which has pharmacological effects such as analgesia, hemostasis, inhibition of thrombosis and anti-tumor, and has been made into some snake venom preparations for clinical application. But because snake venom peptides are the most complex type of animal poisons, it is roughly estimated that there are at least 20 active ingredients contained in each snake venom, mainly including various toxins, enzymes and active peptides, most of which The direct entry of active components into the body may cause the body to produce serious side effects, such as cardiotoxicity, neurotoxicity, etc. These side effects are the main reason for limiting the application of snake venom preparations in clinical treatment.

Introduction Snake-like peptide is a small peptide that mimics the activity of snake venom toxin, not snake venom. It is an active peptide similar to the structure of snake venom toxin. Snake-like peptides are 5 times more effective in reducing dynamic lines than botulinum. Human tests have found that they can effectively reduce 52% wrinkles after 28 days of use.

mechanism of action snake venom peptide acts as an effective smoothing and wrinkle-removing active product by relaxing facial muscles. the mode of action of this active peptide is consistent with the neuromuscular blocking compound Waglerin 1 of Temple Viper venom. Snake-like peptides act on the postsynaptic membrane and are reversible antagonists of the muscle nicotinic acetylcholine receptor (nmAChR). Snake-like peptide binds to nmAChR's & epsilon; Subunit thus blocks the binding of acetylcholine to the receptor, which eventually leads to the closure of the receptor. In the closed state, sodium ions cannot be ingested, cannot be depolarized, nerve excitation transmission is blocked, and muscles are relaxed.

The application of light-controlled targeted snake venom peptide zinc nano-preparations is easy to enter the brain tissue, and under visible light irradiation, it can target the release of snake venom peptide zinc to achieve the targeted central analgesic effect of snake venom peptide zinc; Through the combination of snake venom peptide and zinc, the snake venom peptide zinc complex is formed, which enhances the stability of the snake venom peptide; finally, the light-controlled targeted snake venom peptide zinc nano preparation is prepared by the emulsification method, and the traditional Chinese medicine photosensitizer is located in the outer layer, snake venom peptide zinc is coated in the inner layer, and the formed nanocapsules are stable in structure.

Last Update：2024-04-09 20:45:29